How CBD Compounds Work Inside Your Body

How CBD Compounds Work Inside Your Body
Photo by Enecta Cannabis extracts on Unsplash

Cannabidiol (CBD) pertains to a type of cannabinoid compound that’s present in cannabis plants, including hemp. It’s a non-psychoactive cannabinoid that won’t make a person feel “high,” unlike tetrahydrocannabinol (THC). 

With anti-inflammatory and antioxidant properties, CBD is believed to play a role in boosting one’s immunity and is thought to help reduce stress and anxiety.

But, how does CBD work inside the body? This article will provide an answer to that question. 

Indirect Mechanism of Action

Cannabidiol (CBD) has no specific binding affinity, and scientists believe that the therapeutic benefits of this cannabinoid compound are brought about by an indirect mechanism of action. By inhibiting and regulating certain neurotransmitters, hormones, and chemicals inside the body, CBD indirectly affects pleasure and motivation, inflammation, pain, sleep, and body temperature. An in-depth discussion of these CBD actions will be provided below.

CBD products, like CBD oil, are most sought because of their promising health benefits, like a stress buster and combatting insomnia, and reasonable prices. While CBD is non-psychedelic, it’s important to learn how will CBD oil show up on a drug test so that users are always safeguarded of the possibilities, especially those who regularly take CBD.

CBD Increases Blood Anandamide Levels

Anandamide is a “bliss molecule” that plays a vital role in pleasure and motivation. Increased blood concentration of anandamide brings a positive effect on the endocannabinoid system – a biological system consisting of cannabinoid receptors and proteins that are linked to nervous system function. 

So, does it mean that CBD can be beneficial in reducing stress and anxiety? Here’s how CBD works indirectly in reducing stress and anxiety:

  • Fatty acid amide hydrolase (FAAH) is inhibited by CBD, breaking down anandamide and weakening it. As FAAH weakens, it leads to an increased blood concentration of anandamide, generating pleasure and motivation. 
  • CBD affects the fatty acid-binding protein (FABP) that binds to anandamide, transporting the enzyme to be broken down by the FAAH. This process leads to a higher anandamide concentration, causing positive effects on mood. 
  • CBD binds to the G-protein receptors, including TRPV-1 receptors. These protein receptors are involved in pain, inflammation, and body temperature regulation. That’s why scientists believe that cannabidiol can help with pain relief and reducing inflammation.

CBD Works as Antioxidant Fighting the Body’s Free Radicals 

In addition to having an antioxidant property, CBD oil is also considered a dietary supplement, but without approved therapeutic claims. It also holds true with CBD skincare products. 

Free radicals are the byproducts of the metabolism of food, drugs, and other substances inside the body, as well as environmental pollution, sun damage, and other external factors that affect the skin and overall health.

Here’s how CBD acts as an antioxidant in the body:

  • Cannabidiol’s antioxidant activity and its related derivatives are related to hydrogen and electron abstractions. Abstraction refers to the removal of an atom or a group of atoms from a molecule by a radical, thus eliminating harmful free radicals from the body.
  • Limonene, a terpene that’s also a cannabinoid compound responsible for the flavor and aroma of cannabis and hemp, has slightly more relevance for CBD’s antioxidant properties than phenyl-pentane, one of the two alcohol groups of CBD.
Photo by Oliver King from Pexels

CBD Reduces Inflammatory Cytokines

A CBD study shows that cannabidiol reduces the levels of inflammatory cytokines. CBD plays an important role in pain perception, reducing different types of body pains by working with immune cells. It helps relieve the signs and symptoms of inflammation, such as redness, swelling, and pain, as manifested in arthritis and other joint disorders.

Here’s how CBD reduce inflammation based on the said study:

  • CBD Inhibits T-cell Proliferation: T-cell is a white blood cell (WBC) that’s valuable in immune system function. It tailors the immune response of the body to specific pathogens. T-cells act like soldiers, searching out and destroying targeted invaders. With CBD inhibiting T-cells, the immune response is restricted, so swelling and inflammation are greatly reduced. 
  • CBD Induces T-cell Apoptosis: Apoptosis is considered “cellular suicide” or programmed cell death. The contents of the cell are packaged into membrane packets for “garbage collection” initiated by immune cells.
  • CBD Reduces Immune Cell Adhesion and Migration: By reducing the movement and adherence of immune cells to tissues, inflammation is reduced.


CBD and other cannabinoid compounds are thought to help reduce the signs and symptoms of various health problems. This cannabinoid is used to aid in pain relief, reduce swelling and inflammation, and combat the body’s free radicals. Also, CBD can help reduce stress and anxiety and improve sleep to combat insomnia. 

Comments are closed.